A bile acid
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12β-Hydroxyisocholic Acid

Item No. 39638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-3α,7α,12β-trihydroxy-cholan-24-oic acid
CAS Number
71883-64-2
Synonyms
  • Lagocholic Acid
  • LCA
Molecular Formula
C24H40O5
Formula Weight
408.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleMethanol: Slightly soluble
SMILES
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@]([C@H](C)CCC(O)=O)([H])CC3)([C@@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
InChi Code
InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20-,22+,23+,24-/m1/s1
InChi Key
BHQCQFFYRZLCQQ-KRHHAYMPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    12β-Hydroxyisocholic acid is a bile acid and an isomer of cholic acid (Item No. 20250).1 Hepatic levels of 12β-hydroxyisocholic acid are elevated in a mouse model of alcoholic liver damage.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamaga, N., Ikebuchi, J., Kohara, H., et al. Analysis of bile acids in urine specimens from healthy humans: Determination of several bile acids with β-hydroxyl and carbonyl groups. J. Biochem. 119(4), 725-730 (1996).

    2. Yi, Z., Liu, X., Liang, L., et al. Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake. Food Funct. 12(7), 2925-2937 (2021).