A gadolinium-based MRI contrast agent
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Gadobutrol

Item No. 39649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SA-8-1425362′5′)-[rel-10-[(2R,3S)-2-(hydroxy-κO)-3-hydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]-gadolinium
CAS Number
770691-21-9
Molecular Formula
C18H31GdN4O9
Formula Weight
604.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
OC[C@H]1[N]23[Gd+3]([N]4(C5)CC3)([N]6(C7)CC4)([OH][C@@H]1CO)([O-]C5=O)([O-]C8=O)([O-]C7=O)[N](CC6)(C8)CC2
InChi Code
InChI=1S/C18H34N4O9.Gd/c23-12-14(15(25)13-24)22-7-5-20(10-17(28)29)3-1-19(9-16(26)27)2-4-21(6-8-22)11-18(30)31;/h14-15,23-25H,1-13H2,(H,26,27)(H,28,29)(H,30,31);/q;+3/p-3/t14-,15-;/m1./s1
InChi Key
ZPDFIIGFYAHNSK-CTHHTMFSSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Gadobutrol is a gadolinium-based MRI contrast agent.1 It enhances the visibility of hepatic tumors in a rat model of hepatocellular carcinoma (HCC) induced by N-nitrosomorpholine when administered at a dose of 0.1 mmol/kg. Gadobutrol (0.1 mmol/kg per day for three weeks) increases memory deficits in the passive avoidance test and decreases immobility time in an open field test in rats.2 Formulations containing gadobutrol have been used as contrast agents for diagnostic MRI in adults and children.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, J., Takahashi, M., Kato, N., et al. Comparison of a 1.0 molar and a 0.5 molar formulation of gadobutrol in dynamic MR imaging of the liver in rats with hepatocellular carcinoma. Magn. Reson. Imaging 17(1), 91-97 (1999).

    2. Solmaz, V., Köse Özlece, H., Fatih Bozkurt, M., et al. Repeated gadoteric acid and gadobutrol exposure causes deterioration of behavior and memory functions in rats: MRI, histopathological and biochemical evidence. Brain Res. 1754:147256, (2021).