An isothiocyanate with anticancer activity
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Erysolin

Item No. 39661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-isothiocyanato-4-(methylsulfonyl)-butane
CAS Number
504-84-7
Molecular Formula
C6H11NO2S2
Formula Weight
193.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=S(C)(CCCCN=C=S)=O
InChi Code
InChI=1S/C6H11NO2S2/c1-11(8,9)5-3-2-4-7-6-10/h2-5H2,1H3
InChi Key
WNCZPWWLBZOFJL-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $156

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    25 mg

    $212

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    Cayman Chemical
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    Product Description

    Erysolin is an isothiocyanate that has been found in E. perofskianum and has anticancer activity.1 It inhibits the proliferation of MCF-7, HeLa, A549, HepG2, and SW480 cells (IC50s = 1.62, 1.12, 5.22, 14, and 8.14 µM, respectively). Erysolin (3 µM) enhances arsenic trioxide-induced apoptosis and cytotoxicity in HL-60, U937, and K562 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B.-L., Zhao, S.-Z., Zhou, H., et al. Synthesis and antitumor activity of erysolin and its metabolites. J. Asian Nat. Prod. Res. 25(4), 369-378 (2023).

    2. Doudican, N.A., Bowling, B., and Orlow, S.J. Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism. Leuk. Res. 34(2), 229-234 (2010).