A PROTAC that drives AR degradation
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ARV-110

Item No. 39662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]-3-pyridazinecarboxamide
CAS Number
2222112-77-6
Synonyms
  • Bavdegalutamide
Molecular Formula
C41H43ClFN9O6
Formula Weight
812.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1C2=CC(N3CCN(CC3)CC4CCN(C5=CC=C(C(N[C@@H]6CC[C@H](CC6)OC7=CC(Cl)=C(C=C7)C#N)=O)N=N5)CC4)=C(F)C=C2C(N1C8CCC(NC8=O)=O)=O
InChi Code
InChI=1S/C41H43ClFN9O6/c42-31-19-28(4-1-25(31)22-44)58-27-5-2-26(3-6-27)45-38(54)33-7-9-36(48-47-33)51-13-11-24(12-14-51)23-49-15-17-50(18-16-49)35-21-30-29(20-32(35)43)40(56)52(41(30)57)34-8-10-37(53)46-39(34)55/h1,4,7,9,19-21,24,26-27,34H,2-3,5-6,8,10-18,23H2,(H,45,54)(H,46,53,55)/t26-,27-,34?
InChi Key
CLCTZVRHDOAUGJ-SYVGMNBRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

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    25 mg

    $195

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    50 mg

    $325

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    Cayman Chemical
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    Product Description

    ARV-110 is a proteolysis-targeting chimera (PROTAC) that contains a cereblon ligand 1-derivative connected to an androgen receptor (AR) ligand by a linker region.1 It reduces AR levels in VCaP prostate cancer cells in a time- and concentration-dependent manner. ARV-110 (1 µM) decreases VCaP cancer cell proliferation. In vivo, ARV-110 reduces tumor volume in a VCaP prostate cancer xenograft model that is resistant to the non-steroidal AR antagonist enzalutamide (Item No. 11596).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crew, A.P., Snyder, L.B., Wang, J., et al. Methods of treating prostate cancer. (2020).