A PD-1/PD-L1 interaction inhibitor
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PD-1/PD-L1 Inhibitor N11

Item No. 39663

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[4-(2,3-dihydro-4-phenyl-1H-indol-1-yl)pyrido[3,2-d]pyrimidin-7-yl]methyl]amino]-2-methyl-1-propanol
CAS Number
2975602-78-7
Synonyms
  • PD-1/PD-L1 Interaction Inhibitor
  • Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor N11
Molecular Formula
C26H27N5O
Formula Weight
425.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
OCC(C)(C)NCC(C=N1)=CC2=C1C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=NC=N2
InChi Code
InChI=1S/C26H27N5O/c1-26(2,16-32)30-15-18-13-22-24(27-14-18)25(29-17-28-22)31-12-11-21-20(9-6-10-23(21)31)19-7-4-3-5-8-19/h3-10,13-14,17,30,32H,11-12,15-16H2,1-2H3
InChi Key
CZQOYRCWBPWJJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    PD-1/PD-L1 inhibitor N11 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1; IC50 = 6.3 nM).1 It increases T cell proliferation in a PD-L1-overexpressing CT26 colon cancer cell and T cell co-culture when used at a concentration of 20 nM. PD-1/PD-L1 inhibitor N11 (20 and 80 nM) promotes T cell infiltration into an in vitro PD-L1-overexpressing murine Lewis lung carcinoma tumor matrix. In vivo, PD-1/PD-L1 inhibitor N11 (20 mg/kg) reduces tumor growth and promotes CD8+ and CD4+ T cell tumor infiltration in a PD-L1-overexpressing murine Lewis lung carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, Y., Wang, Y., Zhang, S., et al. Novel 4-arylindolines containing a pyrido[3,2-d]pyrimidine moiety as the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors for tumor immunotherapy. J. Med. Chem. 66(17), 11815-11830 (2023).