A steroid sulfatase inhibitor
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DU-14

Item No. 39665

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-[(aminosulfonyl)oxy]phenyl]ethyl]-tetradecanamide
CAS Number
186303-55-9
Synonyms
  • (p-O-Sulfamoyl)-N-Tetradecanoyltyramine
Molecular Formula
C22H38N2O4S
Formula Weight
426.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleDMSO: SolubleMethanol: Slightly solubleWater: Slightly soluble
SMILES
O=C(CCCCCCCCCCCCC)NCCC1=CC=C(C=C1)OS(=O)(N)=O
InChi Code
InChI=1S/C22H38N2O4S/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(25)24-19-18-20-14-16-21(17-15-20)28-29(23,26)27/h14-17H,2-13,18-19H2,1H3,(H,24,25)(H2,23,26,27)
InChi Key
MBODHUVGZPZRBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $151

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    Product Description

    DU-14 is a steroid sulfatase inhibitor (IC50 = 55.8 nM).1 It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 38.7 nM).2 In vivo, DU-14 (30 mg/kg), in combination with the steroid precursor dehydroepiandrosterone sulfate (DHEAS; Item No. 15873), potentiates DHEAS reversal of scopolamine-induced amnesia in the passive avoidance test in rats.1 It also prevents scopolamine-induced amnesia in the passive avoidance test in rats when administered at a dose of 30 mg/kg per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, P.K., Rhodes, M.E., Burke, A.M., et al. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine. Life Sci. 60(3), 45-51 (1997).

    2. Selcer, K.W., Hegde, P.V., and Li, P.K. Inhibition of estrone sulfatase and proliferation of human breast cancer cells by nonsteroidal (p-O-sulfamoyl)-N-alkanoyl tyramines. Cancer Res. 57(4), 702-707 (1997).

    3. Rhodes, M.E., Li, P.K., Burke, A.M., et al. Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition. Brain Res. 773(1-2), 28-32 (1997).