A fluorescent probe for hydrophobic regions of proteins
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7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole

Item No. 39668

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4-methoxyphenyl)methyl]-7-nitro-2,1,3-benzoxadiazol-4-amine
CAS Number
33984-50-8
Synonyms
  • NSC 240872
  • MBD
Molecular Formula
C14H12N4O4
Formula Weight
300.3
Purity
≥98%
Emission
530 nm
Excitation
430 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
COC(C=C1)=CC=C1CNC(C2=NON=C23)=CC=C3[N+]([O-])=O
InChi Code
InChI=1S/C14H12N4O4/c1-21-10-4-2-9(3-5-10)8-15-11-6-7-12(18(19)20)14-13(11)16-22-17-14/h2-7,15H,8H2,1H3
InChi Key
IENONFJSMWUIQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $109

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    50 mg

    $196

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    100 mg

    $349

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    250 mg

    $654

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    Product Description

    7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole (MBD) is a fluorescent probe for hydrophobic regions of proteins.1,2 Upon binding to a hydrophobic region of a protein, MBD displays an emission of 530 nm upon excitation at 430 nm.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenner, R.A., and Aboderin, A.A. A new fluorescent probe for protein and nucleoprotein conformation. Binding of 7-(p-methoxybenzylamino)-4-nitrobenzoxadiazole to bovine trypsinogen and bacterial ribosomes. Biochemistry 10(24), 4433-4440 (1971).

    2. Kasahara, Y., Takahashi, K., Nagasawa, S., et al. Formation of a conformationally changed C1r, a subcomponent of the first component of human complement, as an intermediate of its autoactivation reaction. FEBS Lett. 141(1), 128-131 (1982).