An activator of the anticipatory unfolded protein response
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Isomer(s)
35684(R)-ErSO
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(±)-ErSO

Item No. 39676

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[[(1S)-3-carboxy-1-[(1,1-dimethylethoxy)carbonyl]propyl]amino]carbonyl]-L-glutamic acid, 1,5-bis(1,1-dimethylethyl) ester
CAS Number
2407860-40-4
Molecular Formula
C22H13F6NO3
Formula Weight
453.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMF: SolubleDMSO: Slightly solubleEthanol: Slightly soluble
SMILES
O=C1NC2=C(C1(C3=CC=C(C=C3)OC(F)(F)F)C4=CC=C(O)C=C4)C=CC=C2C(F)(F)F
InChi Code
InChI=1S/C22H13F6NO3/c23-21(24,25)17-3-1-2-16-18(17)29-19(31)20(16,12-4-8-14(30)9-5-12)13-6-10-15(11-7-13)32-22(26,27)28/h1-11,30H,(H,29,31)
InChi Key
ZFSRXAHDJSCEDS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

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    10 mg

    $388

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    Cayman Chemical
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    Product Description

    (±)-ErSO is an activator of the anticipatory unfolded protein response (a-UPR) and a racemic mixture of the a-UPR activator (R)-ErSO (Item No. 35684) and its inactive enantiomer (S)-ErSO.1 (±)-ErSO is cytotoxic to MCF-7 cells (IC50 = 42.6 nM), as well as T47D cells when used at concentrations of 0.5 and 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boudreau, M.W., Duraki, D., Wang, L., et al. A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Sci. Transl. Med. 13(603), eabf1383 (2021).