A state-dependent inhibitor of Nav1.7
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GX-674

Item No. 39677

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2-amino-1H-benzimidazol-6-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide
CAS Number
1432913-36-4
Molecular Formula
C21H13ClF2N6O3S2
Formula Weight
534.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
O=S(NC1=NC=NS1)(C2=C(F)C=C(OC3=C(C4=CC5=C(C=C4)N=C(N)N5)C=C(Cl)C=C3)C(F)=C2)=O
InChi Code
InChI=1S/C21H13ClF2N6O3S2/c22-11-2-4-17(12(6-11)10-1-3-15-16(5-10)29-20(25)28-15)33-18-7-14(24)19(8-13(18)23)35(31,32)30-21-26-9-27-34-21/h1-9H,(H3,25,28,29)(H,26,27,30)
InChi Key
NLTQZTZBFNPMDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $61

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    10 mg

    $116

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    25 mg

    $273

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    50 mg

    $484

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    Product Description

    GX-674 is a state-dependent inhibitor of voltage-gated sodium channel 1.7 (Nav1.7).1 It selectively inhibits Nav1.7 in HEK293 cells in a patch-clamp assay at -40 mV over -120 mV, voltages that correspond to steady-state inactivation and the resting closed state of the channel (IC50s = 0.1 and 240 nM, respectively). GX-674 is also selective for Nav1.7 over Nav1.1, Nav1.3-1.5, and Nav1.8 but does inhibit Nav1.2 and, to a lesser extent, Nav1.6.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahuja, S., Mukund, S., Deng, L., et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science 350(6267), aac5464 (2015).