A STAT3 inhibitor
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inS3-54-A18

Item No. 39678

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-2H-pyrrol-2-one
CAS Number
328998-53-4
Molecular Formula
C23H16ClNO2
Formula Weight
373.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
ClC(C=C1)=CC=C1C=C2C=C(C3=CC=CC=C3)N(C4=CC=C(O)C=C4)C2=O
InChi Code
InChI=1S/C23H16ClNO2/c24-19-8-6-16(7-9-19)14-18-15-22(17-4-2-1-3-5-17)25(23(18)27)20-10-12-21(26)13-11-20/h1-15,26H
InChi Key
IMHWQIPPIXOVRK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $203

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    10 mg

    $351

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    25 mg

    $539

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    Cayman Chemical
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    Product Description

    inS3-54-A18 is an inhibitor of STAT3.1 It selectively inhibits the binding of STAT3 to DNA over STAT1 at 25 µM. inS3-54-A18 (20 µM) inhibits STAT3 activity in a reporter assay using MDA-MB-231 breast cancer cells. It induces apoptosis in, and reduces migration and invasion of, A549 non-small cell lung cancer (NSCLC) and MDA-MB-231 cells when used at concentrations of 5 or 10 µM. inS3-54-A18 (200 mg/kg) reduces tumor volume in an A549 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, W., Dong, Z., Chen, Y., et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene 35(6), 783-792 (2016).