An antidepressant
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Viloxazine (hydrochloride)

Item No. 39679

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-ethoxyphenoxy)methyl]-morpholine, monohydrochloride
CAS Number
35604-67-2
Synonyms
  • ICI 58834
Molecular Formula
C13H19NO3 • HCl
Formula Weight
273.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
CCOC1=CC=CC=C1OCC2CNCCO2.Cl
InChi Code
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
InChi Key
HJOCKFVCMLCPTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $32

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    50 mg

    $145

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    100 mg

    $208

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    250 mg

    $439

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    Product Description

    Viloxazine is an antidepressant.1 It selectively inhibits norepinephrine uptake over serotonin (5-HT) uptake in rat hypothalamic synaptosomes (IC50s = 0.9 and >100 µM, respectively). Viloxazine (8 and 16 mg/kg) decreases immobility time in the forced swim test in mice.2 Formulations containing viloxazine have been used in the treatment of depression and attention-deficit hyperactivity disorder (ADHD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blackburn, T.P., Foster, G.A., Greenwood, D.T., et al. Effects of viloxazine, its optical isomers and its major metabolites on biogenic amine uptake mechanisms in vitro and in vivo. Eur. J. Pharmacol. 52(3-4), 367-374 (1978).

    2. Bourin, C., Colombel, M.-C., Malinge, M., et al. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity. J. Psychiatry Neurosci. 16(4), 199-203 (1991).