An ionizable amphiphilic Janus dendrimer mRNA delivery system
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IAJD93

Item No. 39688

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-((2-ethylhexyl)oxy)-2,2-bis(((2-ethylhexyl)oxy)methyl)propyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)butanoate
CAS Number
3076338-50-3
Synonyms
  • Ionizable Amphiphilic Janus Dendrimer 93
Molecular Formula
C39H78N2O6
Formula Weight
671.0
Purity
≥95%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CCCCC(CC)COCC(COCC(CCCC)CC)(COC(CCCN1CCN(CCO)CC1)=O)COCC(CCCC)CC
InChi Code
InChI=1S/C39H78N2O6/c1-7-13-17-35(10-4)28-44-31-39(32-45-29-36(11-5)18-14-8-2,33-46-30-37(12-6)19-15-9-3)34-47-38(43)20-16-21-40-22-24-41(25-23-40)26-27-42/h35-37,42H,7-34H2,1-6H3
InChi Key
NYIYLLRVGXJDIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $208

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    10 mg

    $395

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    25 mg

    $729

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    Product Description

    IAJD93 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.25).1 It co-assembles with mRNA to form dendrimersome nanoparticles (DNPs) in acetate buffer. IAJD93 co-assembled with luciferase mRNA delivers the mRNA to the spleen, liver, lungs, and lymph nodes in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, J., Atochina-Vasserman, E.N., Maurya, D.S., et al. Targeted and equally distributed delivery of mRNA to organs with pentaerythritol-based one-component ionizable amphiphilic Janus dendrimers. J. Am. Chem. Soc. 145(34), 18760-18766 (2023).