A STING agonist and a prodrug form of BDW-OH
Related Products
Active Metabolite(s)
41047BDW-OH
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BDW568

Item No. 39708

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]-acetic acid, methyl ester
CAS Number
335401-44-0
Molecular Formula
C12H12N4O2S2
Formula Weight
308.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleChloroform: SolubleMethanol: Soluble
SMILES
O=C(OC)CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3
InChi Code
InChI=1S/C12H12N4O2S2/c1-6-7(2)20-11-9(6)10-14-15-12(16(10)5-13-11)19-4-8(17)18-3/h5H,4H2,1-3H3
InChi Key
RNNRGNUAQCUYEG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH.1 It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, J., Tang, Z., Selvaraju, M., et al. Cellular target deconvolution of small molecules using a selection-based genetic screening platform. ACS Cent. Sci. 8(10), 1424-1434 (2022).