A cationic lipid
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SAINT C-18

Item No. 39709

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-[(10Z)-1-(9Z)-9-octadecen-1-yl-10-nonadecen-1-yl]-pyridinium, monochloride
CAS Number
187587-97-9
Synonyms
  • SAINT-2
  • SAINT-7
  • SAINT-18
  • Synthetic Amphiphile INTeraction C-18
Molecular Formula
C43H78N • Cl
Formula Weight
644.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in chloroform
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleChloroform: Soluble
SMILES
C[N+]1=CC=C(C=C1)C(CCCCCCCC/C=C\CCCCCCCC)CCCCCCCC/C=C\CCCCCCCC.[Cl-]
InChi Code
InChI=1S/C43H78N.ClH/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-42(43-38-40-44(3)41-39-43)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2;/h18-21,38-42H,4-17,22-37H2,1-3H3;1H/q+1;/p-1/b20-18-,21-19-;
InChi Key
FQKXELHZMFODBN-YIQDKWKASA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

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    Product Description

    SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.1,2,3,4 Complexes of SAINT C-18 with plasmid DNA encoding pigment epithelium-derived factor (PEDF) inhibit corneal neovascularization induced by complexes of SAINT C-18 with plasmid DNA encoding FGF2, also known as basic FGF, in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van der Woude, I., Wagenaar, A., Meekel, A.A.P., et al. Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery. Proc. Natl. Acad. Sci. USA 94(4), 1160-1165 (1997).

    2. Kuo, C.-N., Yang, L.-C., Yang, C.-T., et al. Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis. Exp. Eye Res. 89(5), 678-685 (2009).

    3. van der Gun, B.T.F., Monami, A., Laarmann, S., et al. Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2. J. Control Release 123(3), 228-238 (2007).

    4. Adrian, J.E., Morselt, H.W., Süss, R., et al. Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells. J. Control Release 144(3), 341-349 (2010).