An antibiotic and a major constituent of polymyxin B
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Polymyxin B2 (sulfate)

Item No. 39720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
108965-69-1
Molecular Formula
C55H96N16O13 • XH2SO4
Formula Weight
1189.5
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
NCC[C@@H](C(N[C@H]1CCNC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)CCN)=O)CCN)=O)=O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC(CCCCC(C)C)=O)CCN)=O)=O.O=S(O)(O)=O
InChi Code
InChI=1S/C55H96N16O13.H2O4S/c1-30(2)12-10-11-15-43(74)62-35(16-22-56)50(79)71-45(33(6)73)55(84)67-38(19-25-59)47(76)66-40-21-27-61-54(83)44(32(5)72)70-51(80)39(20-26-60)64-46(75)36(17-23-57)65-52(81)41(28-31(3)4)68-53(82)42(29-34-13-8-7-9-14-34)69-48(77)37(18-24-58)63-49(40)78;1-5(2,3)4/h7-9,13-14,30-33,35-42,44-45,72-73H,10-12,15-29,56-60H2,1-6H3,(H,61,83)(H,62,74)(H,63,78)(H,64,75)(H,65,81)(H,66,76)(H,67,84)(H,68,82)(H,69,77)(H,70,80)(H,71,79);(H2,1,2,3,4)/t32-,33-,35+,36+,37+,38+,39+,40+,41+,42-,44+,45+;/m1./s1
InChi Key
RUXJQUSBLROJMB-XYAYNPGCSA-N
Origin
Bacterium/Pseudomonas sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Polymyxin B2 is an antibiotic and a major constituent of the cationic lipopeptide antibiotic polymyxin B (Item No. 14157) originally isolated from B. polymyxa.1 It is active against P. aeruginosa, A. baumannii, K. pneumoniae, and E. cloacae strains (MICs = 1-2, 0.5-1, 0.25-0.5, and 0.25-1 µg/ml, respectively). In vivo, polymyxin B2 (4 mg/kg) reduces the number of blood colony-forming units (CFUs) in a mouse model of P. aeruginosa blood infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, K.D., Azad, M.A.K., Wang, J., et al. Antimicrobial activity and toxicity of the major lipopeptide components of polymyxin B and colistin: Last-line antibiotics against multidrug-resistant Gram-negative bacteria. ACS Infect. Dis. 1(11), 568-575 (2015).