A tachykinin neuropeptide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Kassinin (frog) (trifluoroacetate salt)

Item No. 39727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C59H95N15O18S • XCF3COOH
Formula Weight
1334.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
DVPKSDQFVGLM-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@H](C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)CC(O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C59H95N15O18S.C2HF3O2/c1-30(2)24-38(53(86)66-35(49(63)82)20-23-93-7)65-44(77)28-64-58(91)47(31(3)4)72-55(88)39(25-33-14-9-8-10-15-33)69-52(85)37(18-19-43(62)76)67-54(87)40(27-46(80)81)70-56(89)41(29-75)71-51(84)36(16-11-12-21-60)68-57(90)42-17-13-22-74(42)59(92)48(32(5)6)73-50(83)34(61)26-45(78)79;3-2(4,5)1(6)7/h8-10,14-15,30-32,34-42,47-48,75H,11-13,16-29,60-61H2,1-7H3,(H2,62,76)(H2,63,82)(H,64,91)(H,65,77)(H,66,86)(H,67,87)(H,68,90)(H,69,85)(H,70,89)(H,71,84)(H,72,88)(H,73,83)(H,78,79)(H,80,81);(H,6,7)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,47-,48-;/m0./s1
InChi Key
JMWVNRUMCGLLNK-ZQTAIANPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $131

    Add

    10 mg

    $248

    Add
    Product Description

    Kassinin is a tachykinin neuropeptide and agonist of the neurokinin-2 (NK2) and NK3 receptors.1,2,3,4 It is selective for the NK2 and NK3 receptors over the NK1 receptor.4 Kassinin (1 µM) increases the short-circuit current in isolated frog skin.5 It induces contractions in isolated guinea pig ileum and isolated rabbit jejunum in a concentration-dependent manner.3 Kassinin decreases blood pressure in anesthetized guinea pigs (ED50 = 1,832 pmol/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anastasi, A., Montecucchi, P., Erspamer, V., et al. Amino acid composition and sequence of kassinin, a tachykinin dodecapeptide from the skin of the African frog Kassina senegalensis. Experientia 33(7), 857-858 (1977).

    2. Hancock, J.C., and Hoover, D.B. Effect of substance P and other tachykinins on arterial pressure in guinea-pigs. J. Auton. Pharmacol. 5(1), 25-30 (1985).

    3. Holzer-Petsche, U., Schimek, E., Amann, R., et al. In vivo and in vitro actions of mammalian tachykinins. Naunyn Schmiedebergs Arch. Pharmacol. 330(2), 130-135 (1985).

    4. Regoli, D., Drapeau, G., Dion, S., et al. New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization. Trends Pharmacol. Sci. 9(8), 290-295 (1988).

    5. Lippe, C., Bellantuono, V., Ardizzone, C., et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides 25(11), 1971-1975 (2004).