A neuropeptide
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Product Categories

Product Type

Biochemicals
Peptides
Neuropeptides

Research Area

Neuroscience

Buccalin A (trifluoroacetate salt)

Item No. 39728

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-methionyl-L-α-aspartyl-L-seryl-L-leucyl-L-alanyl-L-phenylalanyl-L-serylglycylglycyl-L-leucinamide, trifluoroacetate salt
Molecular Formula
C45H72N12O15S • XCF3COOH
Formula Weight
1053.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
GMDSLAFSGGL-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]NCC(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)C)=O)=O)=O)CC(O)=O)=O)CCSC)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C45H72N12O15S.C2HF3O2/c1-23(2)14-28(38(47)65)52-36(62)20-48-35(61)19-49-40(67)32(21-58)56-43(70)30(16-26-10-8-7-9-11-26)53-39(66)25(5)50-42(69)29(15-24(3)4)54-45(72)33(22-59)57-44(71)31(17-37(63)64)55-41(68)27(12-13-73-6)51-34(60)18-46;3-2(4,5)1(6)7/h7-11,23-25,27-33,58-59H,12-22,46H2,1-6H3,(H2,47,65)(H,48,61)(H,49,67)(H,50,69)(H,51,60)(H,52,62)(H,53,66)(H,54,72)(H,55,68)(H,56,70)(H,57,71)(H,63,64);(H,6,7)/t25-,27-,28-,29-,30-,31-,32-,33-;/m0./s1
InChi Key
KNOFCWVPSRPVHF-KXYLNWTBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $471

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    10 mg

    $792

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    25 mg

    $1,485

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    Product Description

    Buccalin A is a neuropeptide that is found in gastropod motor neurons and is involved in neuromuscular signaling.1 It reduces current-induced muscle contraction amplitude but not muscle relaxation rate in isolated and washed A. californica accessory radula closer (ARC) muscle fibers when used at a concentration of 10 nM. Buccalin A (10 µM) decreases the amplitude of inhibitory post-synaptic currents (IPSCs) in isolated and perfused voltage-clamped A. californica buccal ganglia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cropper, E.C., Miller, M.W., Tenenbaum, R., et al. Structure and action of buccalin: A modulatory neuropeptide localized to an identified small cardioactive peptide-containing cholinergic motor neuron of Aplysia californica. Proc. Natl. Acad. Sci. USA 85(16), 6177-6181 (1988).

    2. Baux, G., Fossier, P., Trudeau, L.E., et al. Transmitter release and calcium currents at an Aplysia buccal ganglion synapse--II. Modulation by presynaptic receptors. Neuroscience 53(2), 581-593 (1993).