A σ2 receptor ligand
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WLB-89462

Item No. 39736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[2-ethyl-5-(3-methyl-5-isoxazolyl)-4-pyrimidinyl]-1-piperidinyl]-1-(4-morpholinyl)-ethanone
CAS Number
2849471-75-4
Molecular Formula
C21H29N5O3
Formula Weight
399.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CN1CCC(CC1)C2=C(C3=CC(C)=NO3)C=NC(CC)=N2)N4CCOCC4
InChi Code
InChI=1S/C21H29N5O3/c1-3-19-22-13-17(18-12-15(2)24-29-18)21(23-19)16-4-6-25(7-5-16)14-20(27)26-8-10-28-11-9-26/h12-13,16H,3-11,14H2,1-2H3
InChi Key
HPBOMWKBZHYYGE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $76

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    10 mg

    $138

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    50 mg

    $413

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    Product Description

    WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).1 It selectively binds to the σ2 receptor (Ki = 13 nM) over the σ1 receptor (Ki = 1,777 nM). WLB-89462 (10 µM) prevents decreases in the number of dopaminergic neurons in an in vitro model of neurodegeneration using primary rat neurons and induced by the neurotoxin N-methyl-4-phenylpyridinium (MPP+). In vivo, WLB-89462 (10 mg/kg) improves short-term memory in the T-maze in rats in a model of Alzheimer’s disease induced by hippocampal amyloid-β peptide injection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Christmann, U., Díaz, J.L., Pascual, R., et al. Discovery of WLB-89462, a new drug-like and highly selective σ2 receptor ligand with neuroprotective properties. J. Med. Chem. 66(17), 12499-12519 (2023).