A NAPE-PLD activator
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VU534

Item No. 39744

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-4-piperidinecarboxamide
CAS Number
923509-20-0
Synonyms
  • N-Acyl-Phosphatidylethanolamine-Hydrolysing Phospholipase D Activator 534
  • NAPE-PLD Activator 534
Molecular Formula
C21H22FN3O3S2
Formula Weight
447.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
CC1=CC(C)=C2C(N=C(NC(C3CCN(S(=O)(C4=CC=C(F)C=C4)=O)CC3)=O)S2)=C1
InChi Code
InChI=1S/C21H22FN3O3S2/c1-13-11-14(2)19-18(12-13)23-21(29-19)24-20(26)15-7-9-25(10-8-15)30(27,28)17-5-3-16(22)4-6-17/h3-6,11-12,15H,7-10H2,1-2H3,(H,23,24,26)
InChi Key
RLHUIVPGYWWIQZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $93

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    10 mg

    $176

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    25 mg

    $410

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    50 mg

    $740

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    Product Description

    VU534 is an activator of N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD), which hydrolyzes NAPEs into N-acyl ethanolamines (NAEs) and phosphatidic acid.1 It increases NAPE-PLD activity in cell-free assays (EC50s = 0.3 and 0.93 µM for the recombinant mouse and human enzymes, respectively). VU534 (20 µM) also increases NAPE-PLD activity in RAW 264.7 cells, an effect that can be blocked by the NAPE-PLD inhibitor bithionol (Item No. 21844), and in HepG2 cells (EC50 = 1.5 µM). It also inhibits soluble epoxide hydrolase (sEH) with a maximal inhibition of 55% and weakly inhibits fatty acid amide hydrolase (FAAH). VU534 (10 µM) increases efferocytosis in isolated wild-type mouse bone marrow-derived macrophages (BMDMs) but not in BMDMs isolated from Napepld-/- mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zarrow, J.E., Alli-Oluwafuyi, A.M., Youwakim, C.M., et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem. Biol. 18(8), 1891-1904 (2023).