A sterone ERα agonist
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10-Chloroestra-1,4-diene-3,17-dione

Item No. 39758

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10-chloro-estra-1,4-diene-3,17-dione
CAS Number
91413-55-7
Synonyms
  • 10-chloro-1,4-Estradiene
Molecular Formula
C18H21ClO2
Formula Weight
304.8
Purity
≥95%
Formulation
A 10 mg/ml solution in chloroform
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/ml
λmax
241 nm
SMILES
Cl[C@@]12[C@]3([H])[C@](CCC1=CC(C=C2)=O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
InChi Code
InChI=1S/C18H21ClO2/c1-17-8-7-15-13(14(17)4-5-16(17)21)3-2-11-10-12(20)6-9-18(11,15)19/h6,9-10,13-15H,2-5,7-8H2,1H3/t13-,14-,15-,17-,18+/m0/s1
InChi Key
DMUVDGYKPICJEM-FTAMUGHTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    10-Chloroestra-1,4-diene-3,17-dione is a sterone agonist of estrogen receptor α (ERα).1 It increases reporter gene expression in S. cerevisiae (EC50 = 0.36 nM for the human receptor). It also is an aromatase inhibitor (IC50 = 2.4 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, H., Shiozawa, T., Terao, Y., et al. By-products produced by the reaction of estrogens with hypochlorous acid and their estrogen activities. J. Health Sci. 52(2), 124-131 (2006).

    2. R., J., P., T., É., K., et al. Synthesis, biological evaluation and docking studies of 13-epimeric 10-fluoro- and 10-chloroestra-1,4-dien-3-ones as potential aromatase inhibitors. Molecules 24(9), 1783 (2019).