A triterpenoid with diverse biological activities
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Ganoderenic Acid D

Item No. 39774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7β,20E)-7-hydroxy-3,11,15,23-tetraoxo-lanosta-8,20(22)-dien-26-oic acid
CAS Number
100665-43-8
Molecular Formula
C30H40O7
Formula Weight
512.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
CC1(C)C(CCC2(C)C3=C(C4(C(CC(C4(CC3=O)C)/C(C)=C/C(CC(C)C(O)=O)=O)=O)C)[C@@H](O)CC12)=O
InChi Code
InChI=1S/C30H40O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h10,16,18-19,21,32H,8-9,11-14H2,1-7H3,(H,36,37)/b15-10+/t16?,18?,19-,21?,28?,29?,30?/m0/s1
InChi Key
JGWQYLZHPPFHEH-UJSUDUSHSA-N
Origin
Fungus/Ganoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

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    10 mg

    $380

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    25 mg

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    Product Description

    Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 734 µM).2 Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively).3 It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 13.77 µM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Komoda, Y., Nakamura, H., Ishihara, S., et al. Structures of new terpenoid constituents of Ganoderma lucidum (Fr.) KARST (Polyporaceae). Chem. Pharm. Bull. 33(11), 4829-4835 (1985).

    2. Hai-Bang, T., and Shimizu, K. Structure–activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzyme. Phytochem. Lett. 12, 243-247 (2015).

    3. Ruan, W., Lim, A.H.H., Huang, L.G., et al. Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Nat. Prod. Res. 28(24), 2264-2272 (2014).

    4. Jiao, Y., Xie, T., Zou, L.-H., et al. Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia. Bioorg. Med. Chem. Lett. 26(15), 3556-3561 (2016).