A triterpenoid with diverse biological activities
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Isomer(s)
11712β-Elemonic Acid
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Ganoderiol F

Item No. 39775

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
26,27-dihydroxy-lanosta-7,9(11),24-trien-3-one
CAS Number
114567-47-4
Molecular Formula
C30H46O3
Formula Weight
454.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: SolubleChloroform: SolubleDichloromethane: SolubleDMSO: SolubleEthyl Acetate: Soluble
SMILES
C[C@]1(CC[C@]2([H])[C@H](C)CC/C=C(CO)/CO)C(C3=CC[C@@]12C)=CC[C@](C(C)4C)([H])[C@@]3(CCC4=O)C
InChi Code
InChI=1S/C30H46O3/c1-20(8-7-9-21(18-31)19-32)22-12-16-30(6)24-10-11-25-27(2,3)26(33)14-15-28(25,4)23(24)13-17-29(22,30)5/h9-10,13,20,22,25,31-32H,7-8,11-12,14-19H2,1-6H3/t20-,22-,25+,28-,29-,30+/m1/s1
InChi Key
JVGJXXNUVVQEIG-MCKXIFHVSA-N
Origin
Fungus/Ganoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $72

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    1 mg

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    5 mg

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    Product Description

    Ganoderiol F is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It reduces LPS-induced nitric oxide (NO) production and increases heme oxygenase-1 (HO-1) levels in RAW 264.7 cells when used at a concentration of 50 µM.1 Ganoderiol F is a farnesoid X receptor (FXR) agonist, inducing reporter gene expression in HEK293 cells expressing the recombinant human receptor (EC50 = 5 µM).2 It inhibits complement-dependent hemolysis of isolated sheep red blood cells (IC50 = 48 µM).3 Ganoderiol F also reduces HIV-1 viral proliferation in MT-4 cells (IC50 = 7.8 µg/ml).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, S., Nguyen, V.T., Tae, N., et al. Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells. Toxicol. Appl. Pharmacol. 280(3), 434-442 (2014).

    2. Grienke, U., Mihály-Bison, J., Schuster, D., et al. Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum. Bioorg. Med. Chem. 19(22), 6779-6791 (2011).

    3. Min, B.S., Gao, J.J., Hattori, M., et al. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 67(9), 811-814 (2001).

    4. El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49(6), 1651-1657 (1998).