A triterpenoid with diverse biological activities
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Ganodermanondiol

Item No. 39776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
24S,25-dihydroxy-lanosta-7,9(11)-dien-3-one
CAS Number
107900-76-5
Molecular Formula
C30H48O3
Formula Weight
456.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
C[C@]1(CC[C@]2([H])[C@H](C)CC[C@H](O)C(C)(O)C)C(C3=CC[C@@]12C)=CC[C@](C(C)4C)([H])[C@@]3(CCC4=O)C
InChi Code
InChI=1S/C30H48O3/c1-19(9-12-25(32)27(4,5)33)20-13-17-30(8)22-10-11-23-26(2,3)24(31)15-16-28(23,6)21(22)14-18-29(20,30)7/h10,14,19-20,23,25,32-33H,9,11-13,15-18H2,1-8H3/t19-,20-,23+,25+,28-,29-,30+/m1/s1
InChi Key
AAJIHHYEPHRIET-XEFAKFPISA-N
Origin
Fungus/Ganoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

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    10 mg

    $484

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    Product Description

    Ganodermanondiol is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4,5 It inhibits the proliferation of Meth A sarcoma and LLC1 lung carcinoma cells (IC50s = 3.4 and 12.5 µg/ml, respectively).2 Ganodermanondiol (20 µM) reduces the viability of RAW 264.7 macrophages.3 It inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by N-formyl-Met-Leu-Phe (fMLF; Item No. 21495) and cytochalasin B (Item No. 11328) with IC50 values of 6.36 and 5.01 µg/ml, respectively.4 Ganodermanondiol inhibits complement-dependent hemolysis of isolated sheep red blood cells (IC50 = 41.7 µM).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akihisa, T., Nakamura, Y., Tagata, M., et al. Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem. Biodivers. 4(2), 224-231 (2007).

    2. Min, B.S., Gao, J.J., Nakamura, N., et al. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull. (Tokyo) 48(7), 1026-1033 (2000).

    3. Choi, S., Nguyen, V.T., Tae, N., et al. Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells. Toxicol. Appl. Pharmacol. 280(3), 434-442 (2014).

    4. Thang, T.D., Kuo, P.-C., Hwang, T.-L., et al. Triterpenoids and steroids from Ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release. Molecules 18(11), 14285-14292 (2013).

    5. Min, B.S., Gao, J.J., Hattori, M., et al. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 67(9), 811-814 (2001).