An ionizable cationic lipid
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Lipid C2

Item No. 39783

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N4-bis[2-[bis(2-hydroxytetradecyl)amino]ethyl]-1,4-piperazinedipropanamide
CAS Number
3003022-09-8
Synonyms
  • MIC1
Molecular Formula
C70H142N6O6
Formula Weight
1163.9
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleDMSO: Soluble
SMILES
O=C(NCCN(CC(O)CCCCCCCCCCCC)CC(CCCCCCCCCCCC)O)CCN1CCN(CCC(NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CC1
InChi Code
InChI=1S/C70H142N6O6/c1-5-9-13-17-21-25-29-33-37-41-45-65(77)61-75(62-66(78)46-42-38-34-30-26-22-18-14-10-6-2)55-51-71-69(81)49-53-73-57-59-74(60-58-73)54-50-70(82)72-52-56-76(63-67(79)47-43-39-35-31-27-23-19-15-11-7-3)64-68(80)48-44-40-36-32-28-24-20-16-12-8-4/h65-68,77-80H,5-64H2,1-4H3,(H,71,81)(H,72,82)
InChi Key
CMQHGIZKEZAQLN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

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    10 mg

    $570

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    50 mg

    $2,088

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    Cayman Chemical
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    Product Description

    Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNPs containing lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3+CD8+ central and CD3+CD8+ effector memory T cells and decrease the percentage of CD3+ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiang, Y., Tian, M., Huang, J., et al. LMP2-mRNA lipid nanoparticle sensitizes EBV-related tumors to anti-PD-1 therapy by reversing T cell exhaustion. J. Nanobiotechnology 21(1), 324 (2023).