A potential impurity in commercial preparations of ALC-0315
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ALC-0315 N-oxide

Item No. 39797

Technical Information
Formal Name
6-((2-hexyldecanoyl)oxy)-N-(6-((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1-amine oxide
CAS Number
3117157-42-0
Molecular Formula
C48H95NO6
Formula Weight
Purity
≥98%
A 10 mg/ml solution in ethanol
Methanol: Soluble
SMILES
OCCCC[N+](CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)([O-])CCCCCCOC(C(CCCCCC)CCCCCCCC)=O
InChi Code
InChI=1S/C48H95NO6/c1-5-9-13-17-19-27-37-45(35-25-15-11-7-3)47(51)54-43-33-23-21-29-39-49(53,41-31-32-42-50)40-30-22-24-34-44-55-48(52)46(36-26-16-12-8-4)38-28-20-18-14-10-6-2/h45-46,50H,5-44H2,1-4H3
InChi Key
KMGFJFQQPFLZCS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    ALC-0315 N-oxide is a potential impurity in commercial preparations of the ionizable cationic amino lipid ALC-0315.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Packer, M., Gyawali, D., Yerabolu, R., et alA novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems. Nat. Commun. 12(1), 6777 (2021).