An NSAID
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Analytical Standard(s)
15161Benzydamine
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Benzydamine (hydrochloride)

Item No. 39808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-1-propanamine, monohydrochloride
CAS Number
132-69-4
Molecular Formula
C19H23N3O • HCl
Formula Weight
345.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
CN(C)CCCOC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3.Cl
InChi Code
InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
InChi Key
HNNIWKQLJSNAEQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 g

    $32

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    10 g

    $61

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    25 g

    $145

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    Product Description

    Benzydamine is a non-steroidal anti-inflammatory drug (NSAID).1 It decreases the viability of THP-1 monocytes, Saos-2 osteosarcoma, and HGF-1 gingival cancer cells (IC50s = 59.08, 30.79, and 52.06 µg/ml, respectively). Benzydamine (10 µg/ml) reduces LPS-induced increases in the levels of IL-6 and TNF-α secreted by THP-1 cells. It decreases the levels of prostaglandin E2 (PGE2; Item No. 14010) and PGF1α (Item No. 15010) in unstimulated or IL-1β- or TNF-α-stimulated primary human gingival fibroblasts when used at a concentration of 1 µM.2 Benzydamine (100 mg/kg) reduces hydrochloric acid levels and increases mucin levels in gastric juices isolated from rats.3 It inhibits carrageenan-induced paw edema in rats when administered orally at a dose of 60 mg/kg or applied topically at 3% (w/w).4 Formulations containing benzydamine have been used in the treatment of acute sore throat. This product is also available as an analytical reference standard (Item No. 15161).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaval, M.E., Cakir, B., Polatli, E., et al. IL-1ß, IL-6 and TNF-α expression levels of macrophage cells induced by benzydamine hydrochloride, benzydamine hydrochloride with chitosan, calcium hydroxide and chlorhexidine medicaments: An ELISA study. Dent. Mater. J. 41(4), 545-551 (2022).

    2. Modéer, T., and Yucel-Lindberg, T. Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1β or tumor necrosis factor α. Acta Odontol. Scand. 57(1), 40-45 (1999).

    3. Catanese, B., Lisciani, R., and Silvestrini, B. Effects of ulcerogenic and antiulcer drugs on gastric secretion in rats. Pharmacol. Res. Commun. 2(2), 83-90 (1970).

    4. Lisciani, R., Barcellona, P.S., and Silvestrini, B. Researches on the topical activity of benzydamine. Eur. J. Pharmacol. 3(2), 157-162 (1968).