A 5-HT6 receptor agonist
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ST1936

Item No. 39811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N,N,2-trimethyl-1H-indole-3-ethanamine
CAS Number
1210-81-7
Molecular Formula
C13H17ClN2
Formula Weight
236.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
ClC1=CC=C2C(C(CCN(C)C)=C(C)N2)=C1
InChi Code
InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3
InChi Key
KSYMELKKLOFABL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $194

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    10 mg

    $323

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    Product Description

    ST1936 is an agonist of the serotonin (5-HT) receptor subtype 5-HT6.1,2 It selectively binds to 5-HT6 (Ki = 31 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, and the serotonin transporter (SERT; Kis = >1,000 nM for all) but also binds to the 5-HT7 receptor (Ki = 168 nM).1 ST1936 induces cAMP accumulation in BHK fibroblasts (EC50 = 16 nM).2 It decreases the basal firing rate of dopaminergic neurons in the ventral tegmental area but not substantia nigra pars compacta in rats in a dose-dependent manner.3 ST1936 (10 and 30 mg/kg) prevents stress-induced decreases in vanilla sugar-sustained appetitive behavior, indicating anti-anhedonic-like activity, in rats.4 It induces self-administration in rats when administered at a dose of 1 mg/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Di Cesare, M.A., Minetti, P., Tarzia, G., et al. 5-halo-tryptamine derivatives used as ligands of the 5-HT6 and/or 5-HT7 serotonin receptors. (2003).

    2. Mattsson, C., Sonesson, C., Sandahl, A., et al. 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg. Med. Chem. Lett. 15(19), 4230-4234 (2005).

    3. Borsini, F., Bordi, F., Poggi, A., et al. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J. Psychopharmacol. 29(7), 802-811 (2015).

    4. Scheggi, S., Marchese, G., Borsini, F., et al. Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models. Behav. Brain Res. 224(1), 35-43 (2011).

    5. Valentini, V., Piras, G., De Luca, M.A., et al. Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement. Neuropharmacology 65, 58-64 (2013).