An internal standard for the quantification of mepivacaine
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Mepivacaine-d3

Item No. 39812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,6-dimethylphenyl)-1-(methyl-d3)piperidine-2-carboxamide
CAS Number
1346597-90-7
Molecular Formula
C15H19D3N2O
Formula Weight
249.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
O=C(C1N(CCCC1)C([2H])([2H])[2H])NC2=C(C=CC=C2C)C
InChi Code
InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18)/i3D3
InChi Key
INWLQCZOYSRPNW-HPRDVNIFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $101

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    5 mg

    $476

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    Product Description

    Mepivacaine-d3 is intended for use as an internal standard for the quantification of mepivacaine by GC- or LC-MS. Mepivacaine is an inhibitor of voltage-gated sodium channels (Navs) and a local anesthetic.1 It inhibits depolarization-induced currents in ND7/23 cells expressing Nav1.8 channels when used at concentrations of 30 and 100 µM. Mepivacaine (2% w/v) reduces lameness in horses with naturally occurring forelimb lameness.2 Formulations containing mepivacaine have been used as local and regional anesthetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leffler, A., Reckzeh, J., and Nau, C. Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur. J. Pharmacol. 630(1-3), 19-28 (2010).

    2. Boorman, S., DeGraves, F., Schumacher, J., et al. Comparison of 2% mepivacaine and a solution of 2% lidocaine/epinephrine administered for median and ulnar nerve blocks in horses with naturally occurring forelimb lameness. Vet. Surg. 51(2), 279-285 (2022).