An active metabolite of sibutramine
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BTS-54-505 (hydrochloride)

Item No. 39828

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-α-(2-methylpropyl)-cyclobutanemethanamine, monohydrochloride
CAS Number
84484-78-6
Molecular Formula
C15H22ClN • HCl
Formula Weight
288.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
NC(CC(C)C)C1(C2=CC=C(Cl)C=C2)CCC1.Cl
InChi Code
InChI=1S/C15H22ClN.ClH/c1-11(2)10-14(17)15(8-3-9-15)12-4-6-13(16)7-5-12;/h4-7,11,14H,3,8-10,17H2,1-2H3;1H
InChi Key
KHRVYINTXCWNRF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $29

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    5 mg

    $106

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    10 mg

    $169

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    25 mg

    $387

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    Product Description

    BTS-54-505 is an active metabolite of sibutramine.1 It inhibits norepinephrine, serotonin (5-HT), and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively). In vivo, BTS-54-505 prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg) and decreases immobility in the Porsolt learned helplessness test in mice when administered at a dose of 10 mg/kg. BTS-54-505 (10 mg/kg) increases colonic temperature, a marker of thermogenesis, and decreases food intake in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luscombe, G.P., Hopcroft, R.H., Tomas, P.C., et al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 28(2), 129-134 (1989).

    2. Liu, Y.-L., Heal, D.J., and Stock, M.J. Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int. J. Obes. Relat. Metab. Disord. 26(9), 1245-1253 (2002).