A 5-HT2B and 5-HT2C receptor agonist
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(+)-Fenfluramine (hydrochloride)

Item No. 39830

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-α-methyl-3-(trifluoromethyl)-benzeneethanamine, monohydrochloride
CAS Number
3239-45-0
Synonyms
  • Dexfenfluramine
Molecular Formula
C12H16F3N • HCl
Formula Weight
267.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
CCN[C@@H](C)CC1=CC(C(F)(F)F)=CC=C1.Cl
InChi Code
InChI=1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1
InChi Key
ZXKXJHAOUFHNAS-FVGYRXGTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $67

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    50 mg

    $107

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    100 mg

    $201

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    Product Description

    (+)-Fenfluramine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT2B and 5-HT2C.1 It induces serotonin release from superfused midbrain synaptosome preparations isolated from wild-type mice, but not 5-HT2B-/- mice, when used at concentrations of 0.5 or 1 µM. (+)-Fenfluramine (3 or 10 mg/kg) reduces food intake in starved wild-type mice but not in starved 5-HT2B-/- mice. It reduces body weight gain in wild-type mice when infused at a dose of 2.5 mg/kg per day for 35 days. Formulations containing (+)-fenfluramine were previously used in the treatment of obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Banas, S.M., Doly, S., Boutourlinsky, K., et al. Deconstructing antiobesity compound action: Requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36(2), 423-433 (2011).