An anesthetic
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Ophthalmology
Pain Research

Proxymetacaine (hydrochloride)

Item No. 39840

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-4-propoxy-benzoic acid, 2-(diethylamino)ethyl ester, monohydrochloride
CAS Number
5875-06-9
Synonyms
  • Proparacaine
Molecular Formula
C16H26N2O3 • HCl
Formula Weight
330.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(OCCN(CC)CC)C1=CC=C(OCCC)C(N)=C1.[H]Cl
InChi Code
InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
InChi Key
BFUUJUGQJUTPAF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $39

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    1 g

    $74

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    Product Description

    Proxymetacaine is an anesthetic.1 Intrathecal administration of proxymetacaine reduces motor function, decreases righting behaviors in the placement test, and increases latency to paw withdrawal in the hot plate test in rats (ED50s = 0.24, 0.3, and 0.16 µmol/kg, respectively). Topical application of proxymetacaine (0.5% w/v) reduces corneal sensitivity in the corneal touch test in dogs.2 Formulations containing proxymetacaine have been used to induce anesthesia prior to ocular surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hung, C.-H., Wang, J.-J., Chen, Y.-C., et al. Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci. Lett. 454(3), (2009).

    2. Herring, I.P., Bobofchak, M.A., Landry, M.P., et al. Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs. Am. J. Vet. Res. 66(1), 77-80 (2005).