An ionizable cationic lipid
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VL422

Item No. 39874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octanedioic acid, 1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] 8,8′-bis(1-octylnonyl) ester
CAS Number
2765519-47-7
Molecular Formula
C62H117NO11
Formula Weight
1052.6
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
CCCCCCCCC(CCCCCCCC)OC(CCCCCCC(OCC(COC(OCCCN(CC)CC)=O)COC(CCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)=O)=O
InChi Code
InChI=1S/C62H117NO11/c1-7-13-17-21-25-33-42-56(43-34-26-22-18-14-8-2)73-60(66)48-39-31-29-37-46-58(64)70-52-55(54-72-62(68)69-51-41-50-63(11-5)12-6)53-71-59(65)47-38-30-32-40-49-61(67)74-57(44-35-27-23-19-15-9-3)45-36-28-24-20-16-10-4/h55-57H,7-54H2,1-6H3
InChi Key
LUQLMJLIEUBIFP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

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    10 mg

    $660

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    Cayman Chemical
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    Product Description

    VL422 is an ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for gene editing in vitro and in vivo. LNPs containing VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene encoding angiopoietin-related protein 3 (ANGPTL3), a protein whose loss-of-function decreases LDL, HDL, and cholesterol plasma levels, induce a deletion in a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rajeev, K.G., Biswas, S., Kasiewicz, L.N., et al. Lipid formulations for gene editing. 1-312 (2022).