A DPP-9 inhibitor
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DPP-9 Inhibitor 42

Item No. 39881

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tert-butyl ((7S)-3r-((2-(5R,6-difluoroisoindolin-2-yl)-2-oxoethyl)amino)adamantan-1s-yl)carbamate
Synonyms
  • Dipeptidyl Peptidase 9 Inhibitor 42
Molecular Formula
C25H33F2N3O3
Formula Weight
461.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(OC(C)(C)C)N[C@](C[C@H](C1)C2)(C[C@@H]1C3)C[C@]23NCC(N4CC5=C(C=C(F)C(F)=C5)C4)=O
InChi Code
InChI=1S/C25H33F2N3O3/c1-23(2,3)33-22(32)29-25-9-15-4-16(10-25)8-24(7-15,14-25)28-11-21(31)30-12-17-5-19(26)20(27)6-18(17)13-30/h5-6,15-16,28H,4,7-14H2,1-3H3,(H,29,32)/t15-,16+,24+,25-
InChi Key
PYOHEUZJJMWWMD-NDKKOABESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC50 = 0.0034 µM).1 It is selective for DDP-9 over DPP-8, DPP-4, DPP-2, fibroblast activation protein (FAP), and prolyl endopeptidase (IC50s = 0.6, >10, >5, 10, and >10 µM, respectively). DPP-9 inhibitor 42 (10 µM) induces lactate dehydrogenase (LDH) release from THP-1 acute monocytic and HL-60 promyeloblast leukemia cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benramdane, S., De Loose, J., Filippi, N., et al. Highly selective inhibitors of dipeptidyl peptidase 9 (DPP9) derived from the clinically used DPP4-inhibitor vildagliptin. J. Med. Chem. 66(18), 12717-12738 (2023).