An inhibitor of GAC
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Glutaminase C Inhibitor 11

Item No. 39883

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenoxy-N-[5-[[(3R)-1-(3-pyridazinyl)-3-pyrrolidinyl]amino]-1,3,4-thiadiazol-2-yl]-benzeneacetamide
CAS Number
3056437-77-2
Molecular Formula
C24H23N7O2S
Formula Weight
473.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(CC1=CC=CC(OC2=CC=CC=C2)=C1)NC3=NN=C(N[C@@H]4CCN(C5=CC=CN=N5)C4)S3
InChi Code
InChI=1S/C24H23N7O2S/c32-22(15-17-6-4-9-20(14-17)33-19-7-2-1-3-8-19)27-24-30-29-23(34-24)26-18-11-13-31(16-18)21-10-5-12-25-28-21/h1-10,12,14,18H,11,13,15-16H2,(H,26,29)(H,27,30,32)/t18-/m1/s1
InChi Key
JOKJBMFEUFULOX-GOSISDBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

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    10 mg

    $783

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    Product Description

    Glutaminase C inhibitor 11 is an inhibitor of glutaminase C (GAC).1 It inhibits GAC enzyme activity (EC50 = 10.64 nM) and reduces the viability of A549 non-small cell lung cancer (NSCLC) cells (IC50 = 4.025 nM). Glutaminase C inhibitor 11 (0.1 and 1 µM) reduces colony formation by, and intracellular glutamate levels in, A549 cells. In vivo, glutaminase C inhibitor 11 (100 mg/kg) reduces tumor growth in an A549 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, H., Du, T., Yang, M., et al. Targeting the subpocket enables the discovery of thiadiazole-pyridazine derivatives as glutaminase C inhibitors. ACS Med. Chem. Lett. 14(10), 1455-1466 (2023).