A turn-on fluorescent probe for biothiols
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DCI-Ac-Py

Item No. 39887

Product Insert (PDF)
Technical Information
Formal Name
2-bromo-4-((E)-2-(3-(dicyanomethylene)-5,5-dimethylcyclohex-1-en-1-yl)vinyl)-6-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)phenyl isonicotinate
Molecular Formula
C30H26BrN3O4
Formula Weight
572.5
Purity
≥98%
Emission
713 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
CC(CC(/C=C/C1=CC(Br)=C(OC(C2=CC=NC=C2)=O)C(/C=C/C(OCC)=O)=C1)=C/3)(C)CC3=C(C#N)\C#N
InChi Code
InChI=1S/C30H26BrN3O4/c1-4-37-27(35)8-7-23-13-20(15-26(31)28(23)38-29(36)22-9-11-34-12-10-22)5-6-21-14-24(25(18-32)19-33)17-30(2,3)16-21/h5-15H,4,16-17H2,1-3H3/b6-5+,8-7+
InChi Key
CBLVMCGKPLKPHF-BSWSSELBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $330

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    10 mg

    $620

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    Product Description

    DCI-Ac-Py is a turn-on fluorescent probe for the detection of biothiols.1 Upon reaction with biothiols, it is converted into DCI-Br-Cou and displays a shift in absorbance from 396 to 541 nm and an emission maximum of 713 nm. DCI-Ac-Py has been used in the study of biothiol fluctuations in the brain in a mouse model of cerebral ischemia-reperfusion injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Y., Ma, M., Shen, L., et al. A fluorescent probe for investigating the role of biothiols in signaling pathways associated with cerebral ischemia-reperfusion injury. Angew Chem. Int. Ed. Engl. 62, e2002310408 (2023).