A promoter of mitochondrial fusion
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Mitochondrial Fusion Promoter M1

Item No. 39909

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,4,6-trichlorophenyl)hydrazone, 1-(5-chloro-2-hydroxyphenyl)-ethanone
CAS Number
219315-22-7
Synonyms
  • M1
Molecular Formula
C14H10Cl4N2O
Formula Weight
364.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
ClC1=CC=C(C(C(C)=NNC2=C(Cl)C=C(Cl)C=C2Cl)=C1)O
InChi Code
InChI=1S/C14H10Cl4N2O/c1-7(10-4-8(15)2-3-13(10)21)19-20-14-11(17)5-9(16)6-12(14)18/h2-6,20-21H,1H3
InChi Key
CYVDGZYJHHYIIU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $53

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    25 mg

    $125

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    50 mg

    $220

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    Product Description

    Mitochondrial fusion promoter M1 is a promoter of mitochondrial fusion.1 It induces elongation of mitochondria in mitofusin-1 knockout (Mfn1-/-) or Mfn2-/- mouse embryonic fibroblasts (MEFs; EC50s = 5.3 and 4.42 µM, respectively) and protects against MPP+-induced mitochondrial fragmentation and cytotoxicity in SH-SY5Y cells when used at a concentration of 5 µM. M1 (1 µM) reduces apoptosis and inhibits decreases in testosterone levels induced by the organophosphate triphenyl phosphate in TM3 mouse Leydig cells.2 In vivo, mitochondrial fusion promoter M1 (2 mg/kg) improves novel object recognition deficits induced by the antitumor antibiotic doxorubicin (Item No. 15007) in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, D., Wang, J., Bonamy, G.M.C., et al. A small molecule promotes mitochondrial fusion in mammalian cells. Angew Chem. Int. Ed. Engl. 51(37), 9302-9305 (2012).

    2. Wang, M., Xu, J., Zhao, Z., et al. Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition. Ecotoxicol. Environ. Saf. 256, 114876 (2023).

    3. Ongnok, B., Maneechote, C., Chunchai, T., et al. Modulation of mitochondrial dynamics rescues cognitive function in rats with 'doxorubicin-induced chemobrain' via mitigation of mitochondrial dysfunction and neuroinflammation. FEBS J. 289(20), 6435-6455 (2022).