An inhibitor of FSP1
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viFSP1

Item No. 39927

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-1-(2,4-dimethoxyphenyl)-1,2-dihydro-4-(4-methyl-2-thiazolyl)-3H-pyrrol-3-one
CAS Number
951945-67-8
Synonyms
  • Versatile Inhibitor of Ferroptosis Suppressor Protein 1
  • Versatile Inhibitor of FSP1
Molecular Formula
C16H17N3O3S
Formula Weight
331.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleChloroform: Soluble
SMILES
COC1=CC=C(N2C(N)=C(C3=NC(C)=CS3)C(C2)=O)C(OC)=C1
InChi Code
InChI=1S/C16H17N3O3S/c1-9-8-23-16(18-9)14-12(20)7-19(15(14)17)11-5-4-10(21-2)6-13(11)22-3/h4-6,8H,7,17H2,1-3H3
InChi Key
OUJMVDXLUWMMEC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $76

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    1 mg

    $129

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    5 mg

    $532

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    Product Description

    viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).1 It induces ferroptosis in glutathione peroxidase 4 (Gpx4) knockout Pfa1 mouse embryonic fibroblasts expressing human or mouse FSP1, an effect that can be reversed by the ferroptosis inhibitor liproxstatin-1 (Item No. 17730).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, T., Mishima, E., Yamada, N., et al. Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation. Nat. Struct. Mol. Biol. 30(11), 1806-1815 (2023).