An ester-derivative of dihydrocaffeic acid with antifibrotic activities
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Caffeic Acid dimethyl ether

Item No. 39933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3,4-dimethoxyphenyl)-2-propenoic acid
CAS Number
2316-26-9
Synonyms
  • 3,4-Dimethoxycinnamic Acid
  • NSC 4323
  • NSC 43569
Molecular Formula
C11H12O4
Formula Weight
208.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
COC(C=C1C=CC(O)=O)=C(C=C1)OC
InChi Code
InChI=1S/C11H12O4/c1-14-9-5-3-8(4-6-11(12)13)7-10(9)15-2/h3-7H,1-2H3,(H,12,13)
InChi Key
HJBWJAPEBGSQPR-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $43

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    50 g

    $77

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    100 g

    $138

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    250 g

    $301

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    Product Description

    Caffeic acid dimethyl ether is an ester-derivative of dihydrocaffeic acid (Item No. 27390) that has been found in C. arabica and has antifibrotic activities.1 It inhibits TGF-β1-induced cell growth in LX-2 hepatic stellate cells when used at a concentration of 20 µM. Caffeic acid dimethyl ether prevents TGF-β1-induced increases in the levels of collagen I, reactive oxygen species (ROS), and NADPH oxidase 4 (NOX4) in LX-2 cells. In vivo, caffeic acid dimethyl ether (20 mg/kg per day) reduces the serum levels of hyaluronic acid, laminin, procollagen type III, and collagen type IV and the liver levels of hydroxyproline in an ethanol- and carbon tetrachloride-induced rat model of hepatic fibrosis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, Q., Li, C., Yang, C.F., et al. Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways. Chem. Biol. Interact. 299, 131-139 (2019).