A triterpenoid glycoside with diverse biological activities
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Rosamultin

Item No. 39939

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2α,3β,19-trihydroxy-urs-12-en-28-oic acid, β-D-glucopyranosyl ester
CAS Number
88515-58-6
Synonyms
  • Tormentic Acid 28-O-glucoside ester
  • Ursolazuroside 1
Molecular Formula
C36H58O10
Formula Weight
650.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C([C@](CC[C@]12C)(CC[C@H]3C)[C@]([C@](O)3C)([H])C1=CC[C@@]4([H])[C@]2(CC[C@](C(C)([C@H]5O)C)([H])[C@@]4(C[C@H]5O)C)C)O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]([C@H]6O)CO
InChi Code
InChI=1S/C36H58O10/c1-18-10-13-36(30(43)46-29-26(41)25(40)24(39)21(17-37)45-29)15-14-33(5)19(27(36)35(18,7)44)8-9-23-32(4)16-20(38)28(42)31(2,3)22(32)11-12-34(23,33)6/h8,18,20-29,37-42,44H,9-17H2,1-7H3/t18-,20-,21-,22+,23-,24-,25+,26-,27-,28+,29+,32+,33-,34-,35-,36+/m1/s1
InChi Key
MLKQAGPAYHTNQQ-BRDPIYJESA-N
Origin
Plant/Argentina anserina (L.) Rydb.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $372

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    10 mg

    $660

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    25 mg

    $1,445

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    Product Description

    Rosamultin is a triterpenoid glycoside that has been found in R. rugosa and has diverse biological activities.1,2,3,4 It inhibits HIV-1 protease by 52.9% in a cell-free assay when used at a concentration of 100 µM.1 Rosamultin (0.01 nM) reduces hydrogen peroxide-induced apoptosis, increases in malondialdehyde (MDA) levels, and decreases in superoxide dismutase (Sod), catalase (Cat), and glutathione peroxidase (Gpx) activities in H9c2 rat cardiomyocytes.2 In vivo, rosamultin (12 mg/kg) increases survival, prevents decreases in body weight, and protects against splenic and intestinal damage in irradiated mice.3 Rosamultin (30 mg/kg, p.o.) inhibits acetic acid-induced writhing in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, J.C., Kim, S.C., Choi, M.R., et al. Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa. J. Med. Food 8(1), 107-109 (2005).

    2. Zhang, L., Liu, Y., Li, J.Y., et al. Protective effect of rosamultin against H2O2-induced oxidative stress and apoptosis in H9c2 cardiomyocytes. Oxid. Med. Cell. Longev. 8415610 (2018).

    3. Liu, N., Niu, M., Luo, S., et al. Rosamultin ameliorates radiation injury via promoting DNA injury repair and suppressing oxidative stress in vitro and in vivo. Chem. Biol. Interact. 393, 110938 (2024).

    4. Jung, H.-J., Nam, J.-H., Choi, J., et al. 19α-hydroxyursane-type triterpenoids: Antinociceptive anti-inflammatory principles of the roots of Rosa rugosa. Biol. Pharm. Bull. 28(1), 101-104 (2005).