A coumaran scaffold and pharmacophore
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2,3-Dihydrobenzofuran

Item No. 39945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
496-16-2
Synonyms
  • Coumaran
  • Benzodihydrofuran
Molecular Formula
C8H8O
Formula Weight
120.1
Purity
≥98%
Formulation (Request formulation change)
A neat liquid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C12=CC=CC=C1OCC2
InChi Code
InChI=1S/C8H8O/c1-2-4-8-7(3-1)5-6-9-8/h1-4H,5-6H2
InChi Key
HBEDSQVIWPRPAY-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $40

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    25 g

    $139

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    Cayman Chemical
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    Product Description

    2,3-Dihydrobenzofuran is a coumaran scaffold and pharmacophore in various synthetic and naturally occuring bioactive molecules.1,2,3 It has been found in A. pichinchensis and is cytotoxic to HeLa cells (IC50 = 23.86 µg/ml).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sánchez-Ramos, M., Encarnación-García, J.G., Marquina-Bahena, S., et al. Cytotoxic activity of wild plant and callus extracts of Ageratina pichinchensis and 2,3-dihydrobenzofuran isolated from a callus culture. Pharmaceuticals (Basel) 16(10), 1400 (2023).

    2. Qin, L., Vo, D.D., Nakhai, A., et al. Diversity-oriented synthesis of libraries based on benzofuran and 2,3-dihydrobenzofuran scaffolds. ACS Comb. Sci. 19(6), 370-376 (2017).

    3. Vargas, D.A., Khade, R.L., Zhang, Y., et al. Biocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds. Angew. Chem. Int. Ed. Engl. 58(30), 10148-10152 (2019).