An anesthetic
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience
Ophthalmology
Pain Research

Oxybuprocaine (hydrochloride)

Item No. 39978

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-3-butoxy-benzoic acid, 2-(diethylamino)ethyl ester, monohydrochloride
CAS Number
5987-82-6
Synonyms
  • Benoxinate
  • Dorsacaine
Molecular Formula
C17H28N2O3 • HCl
Formula Weight
344.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(C(C=C1)=CC(OCCCC)=C1N)OCCN(CC)CC.Cl
InChi Code
InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H
InChi Key
PRGUDWLMFLCODA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

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    10 g

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    Product Description

    Oxybuprocaine is an anesthetic.1 Intrathecal administration of oxybuprocaine reduces motor function, decreases righting behaviors in the placement test, and increases latency to paw withdrawal in the hot plate test in rats (ED50s = 0.43, 0.5, and 0.31 µmol/kg, respectively). Topical application of oxybuprocaine (0.4% w/v) reduces corneal sensitivity in the corneal touch test in dogs.2 Formulations containing oxybuprocaine have been used to induce anesthesia prior to ocular surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hung, C.-H., Wang, J.-J., Chen, Y.-C., et al. Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci. Lett. 454(3), (2009).

    2. Douet, J.-Y., Michel, J., and Regnier, A. Degree and duration of corneal anesthesia after topical application of 0.4% oxybuprocaine hydrochloride ophthalmic solution in ophthalmically normal dogs. Am. J. Vet. Res. 74(10), 1321-1326 (2013).