A negative modulator of mitochondrial calcium uptake
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MCU i4

Item No. 39993

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[4-(diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid, ethyl ester
CAS Number
371924-24-2
Synonyms
  • Mitochondrial Calcium Uptake Inhibitor 4
Molecular Formula
C23H27N3O2
Formula Weight
377.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
O=C(C(C=N1)=C(C2=C1C=CC(C)=C2)NC(C=C3)=CC=C3N(CC)CC)OCC
InChi Code
InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H,5-7H2,1-4H3,(H,24,25)
InChi Key
RIWXBJCWHVMATR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $28

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    10 mg

    $48

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    25 mg

    $97

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    50 mg

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    Product Description

    MCU i4 is a negative modulator of mitochondrial calcium uptake.1 It selectively decreases mitochondrial over cytosolic histamine-induced calcium uptake, but also decreases the mitochondrial membrane potential, in HeLa cells when used at a concentration of 10 µM. MCU i4 binds to mitochondrial calcium uptake protein 1 (Micu1), a regulatory protein of the mitochondrial calcium uniporter (MCU) complex, in a cell-free assay (Kd = 8.4 µM for the mouse protein). It decreases myotube width in differentiated C2C12 skeletal muscle myoblasts in an in vitro model of myotube growth. MCU i4 (2.5 µM) protects against ferroptosis induced by RSL3, erastin (Item No. 17754), or glutamate in HT22 hippocampal cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Di Marco, G., Vallese, F., Jourde, B., et al. A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 30(7), 2321-2331 (2020).

    2. Marmolejo-Garza, A., Krabbendam, I.E., Luu, M.D.A., et al. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 14(11), 772 (2023).