A cyathane diterpenoid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Erinacine C

Item No. 40079

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-O-[(3aR,5aR,6R,7R,10aR)-2,3,3a,4,5,5a,6,7,10,10a-decahydro-8-(hydroxymethyl)-3a,5a-dimethyl-1-(1-methylethyl)cyclohept[e]indene-6,7-diyl]-β-D-xylopyranose
CAS Number
156101-09-6
Synonyms
  • Erinacin C
Molecular Formula
C25H38O6
Formula Weight
434.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC(C(CC[C@]1(C)CC[C@](C)2[C@]3(O[C@@]4(OC[C@@H](O)[C@@H]([C@]4(O[C@]53[H])[H])O)[H])[H])=C1[C@]2(CC=C5CO)[H])C
InChi Code
InChI=1S/C25H38O6/c1-13(2)15-7-8-24(3)9-10-25(4)16(18(15)24)6-5-14(11-26)20-22(25)31-23-21(30-20)19(28)17(27)12-29-23/h5,13,16-17,19-23,26-28H,6-12H2,1-4H3/t16-,17-,19+,20-,21-,22+,23+,24-,25-/m1/s1
InChi Key
DMPGFSQMXITJPT-ZCKYJUNOSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $395

    Add

    1 mg

    $671

    Add

    5 mg

    $1,975

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Erinacine C is a cyathane diterpenoid that has been found in H. erinaceum and has diverse biological activities.1,2,3,4 It inhibits transcription of the genes encoding the bacteriocins mutacin IV, mutacin V, and mutacin VI, which are S. mutans virulence factors, in reporter assays using S. mutans.2 Erinacine C (1 mM) increases the production of nerve growth factor (NGF) in mouse astroglial cells.1 It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 29.22 µM).3 Erinacine C (2 mg/kg) reduces mild traumatic brain injury-induced motor deficits and neuronal cell death in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawagishi, H., Shimada, A., Shirai, R., et al. Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis from the mycelia of Hericium erinaceum. Tetrahedron Lett. 35(10), 1569-1572 (1994).

    2. Premnath, P., Reck, M., Wittstein, K., et al. Screening for inhibitors of mutacin synthesis in Streptococcus mutans using fluorescent reporter strains. BMC Microbiol. 18(1), 24 (2018).

    3. Wei, J., Li, J.-Y., Feng, X.-L., et al. Unprecedented neoverrucosane and cyathane diterpenoids with anti-neuroinflammatory activity from cultures of the culinary-medicinal mushroom Hericium erinaceus. Molecules 28(17), 6380 (2023).

    4. K.F., L., Hsieh, Y.Y., Tung, S.Y., et al. The cerebral protective effect of novel erinacines from Hericium erinaceus Mycelium on in vivo mild traumatic brain injury animal model and primary mixed glial cells via Nrf2-dependent pathways. Antioxidants (Basel) 13(3), 371 (2024).