A sesquiterpenoid with diverse biological activities
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Valerenic Acid

Item No. 40113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
CAS Number
3569-10-6
Molecular Formula
C15H22O2
Formula Weight
234.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
[H][C@@]12[C@H](C)CC[C@@H](/C=C(C(O)=O)\C)C1=C(CC2)C
InChi Code
InChI=1S/C15H22O2/c1-9-4-6-12(8-11(3)15(16)17)14-10(2)5-7-13(9)14/h8-9,12-13H,4-7H2,1-3H3,(H,16,17)/b11-8+/t9-,12+,13-/m1/s1
InChi Key
FEBNTWHYQKGEIQ-SUKRRCERSA-N
Origin
Plant/Valeriana officinalis L.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Valerenic acid is a sesquiterpenoid that has been found in V. officinalis and has diverse biological activities.1,2,3,4,5 It selectively transactivates retinoid X receptor β (RXRβ) over RXRα and RXRγ in reporter assays using HEK293T cells (EC50s = 5.2, 27, and 43 µM, respectively), as well as the retinoic acid receptors (RARs), peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), farnesoid X receptor (FXR), constitutive androstane receptor (CAR), vitamin D receptor (VDR), and pregnane X receptor (PXR) at 30 µM.2 Valerenic acid also enhances GABA-induced activation of α1β2γ2-subunit containing GABA receptors in CHO cells (EC50 = 12.6 µM).3 It is cytotoxic to GLC-4 lung and COLO 320 colon cancer cells (IC50s = 127 and 124 µM, respectively).1 Valerenic acid (100 mg/kg, i.p.) decreases motor performance in the rotarod test and increases pentobarbital-induced sleeping time in mice.4 It increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at a dose of 12 mg/kg.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bos, R., Hendriks, H., Scheffer, J.J., et al. Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine 5(3), 219-225 (1998).

    2. Merk, D., Grisoni, F., Friedrich, L., et al. Computer-assisted discovery of retinoid X receptor modulating natural products and isofunctional mimetics. J. Med. Chem. 61(12), 5442-5447 (2018).

    3. Syafni, N., Faleschini, M.T., Garifulina, A., et al. Clerodane diterpenes from Casearia corymbosa as allosteric GABAA receptor modulators. J. Nat. Prod. 85(5), 1201-1210 (2022).

    4. Hendriks, H., Bos, R., Woerdenbag, H.J., et al. Central nervous depressant activity of valerenic acid in the mouse. Planta Med. 51(1), 28-31 (1985).

    5. Pinder, N.E., Ligocki, I.Y., Horton, B.M., et al. Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice. Behav. Brain Res. 457:114717, (2024).