A G protein-activating peptide
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Mastoparan 7 (trifluoroacetate salt)

Item No. 40115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Mas7
Molecular Formula
C67H124N18O15 • XCF3COOH
Formula Weight
1421.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
INLKALAALAKALL-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
[H]N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)C)=O)=O)C)=O)=O)C)=O)C)=O)=O)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C67H124N18O15.C2HF3O2/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3;3-2(4,5)1(6)7/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100);(H,6,7)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-;/m0./s1
InChi Key
BJNSONOHGKNLFN-SPJAXDBWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $109

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    1 mg

    $207

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    5 mg

    $654

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    10 mg

    $1,089

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    Product Description

    Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan (Item No. 20240).1 It decreases the affinity of acetylcholine (ACh) to porcine brain muscarinic ACh receptors (mAChRs) when used at a concentration of 30 µM and induces GDP/GTP exchange by Gi in a concentration-dependent manner. Mastoparan 7 (1 µM) also induces activation of Gαo in, and increases dendritic spine density of, primary rat hippocampal neurons.2 It induces contractions in isolated perfused rat tail arteries (EC50 = 44.1 nM).3 Immunization with a vaccine against cocaine in combination with mastoparan 7 as an adjuvant increases hapten-specific serum IgG levels and decreases cocaine-induced locomotion in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Higashijima, T., Burnier, J., and Ross, E.M. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. The Journal of Biological Chemisty 265(24), 14176-14186 (1990).

    2. Ramírez, V.T., Ramos-Fernández, E., and Inestrosa, N.C. The Gαo activator mastoparan-7 promotes dendritic spine formation in hippocampal neurons. Neural Plast. 4258171 (2016).

    3. Grześk, G., Malinowski, B., Grześk, E., et al. Direct regulation of vascular smooth muscle contraction by mastoparan-7. Biomed. Rep. 2(1), 34-38 (2014).

    4. St. John, A.L., Choi, H.W., Walker, Q.D., et al. Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy. NPJ Vaccines 5(1), 12 (2020).