A potential impurity in commercial preparations of cabazitaxel
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De-Boc-Cabazitaxel

Item No. 40116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR,βS)-β-amino-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
CAS Number
1638286-64-2
Synonyms
  • Cabazitaxel Impurity IV
Molecular Formula
C40H49NO12
Formula Weight
735.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
O[C@@]1(C(C)(C)C([C@H]2OC)=C([C@@H](OC([C@H](O)[C@@H](N)C3=CC=CC=C3)=O)C1)C)[C@@H](OC(C4=CC=CC=C4)=O)[C@]5([H])[C@@]6(OC(C)=O)[C@@](OC6)([H])C[C@H](OC)[C@@]5(C)C2=O
InChi Code
InChI=1S/C40H49NO12/c1-21-25(51-36(46)30(43)29(41)23-14-10-8-11-15-23)19-40(47)34(52-35(45)24-16-12-9-13-17-24)32-38(5,33(44)31(49-7)28(21)37(40,3)4)26(48-6)18-27-39(32,20-50-27)53-22(2)42/h8-17,25-27,29-32,34,43,47H,18-20,41H2,1-7H3/t25-,26-,27+,29-,30+,31+,32-,34-,38+,39-,40+/m0/s1
InChi Key
ONJGHPJYUCCBGB-KWIOUIIFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    De-Boc-Cabazitaxel is a potential impurity in commercial preparations of the semisynthetic taxane cabazitaxel.1 It has also been used in the synthesis of tubulin-targeting fluorescent dyes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Y., Feng, F., Chen, L., et al. Isolation, identification and characterization of potential impurities in cabazitaxel and their formation. Magn. Reson. Chem. 52(12), 783-788 (2014).

    2. Grimm, F., Nizamov, S., and Belov, V.N. Green-emitting rhodamine dyes for vital labeling of cell organelles using STED super-resolution microscopy. Chembiochem 20(17), 2248-2254 (2019).