A thymoleptic and tricyclic antidepressant
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Melitracen (hydrochloride)

Item No. 40117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
CAS Number
10563-70-9
Synonyms
  • Melitracene
  • U-24973A
Molecular Formula
C21H25N • HCl
Formula Weight
327.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly SolubleDMSO: SolubleWater: Slightly Soluble
SMILES
CC1(C2=C(/C(C3=C1C=CC=C3)=C/CCN(C)C)C=CC=C2)C.Cl
InChi Code
InChI=1S/C21H25N.ClH/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21;/h5-8,10-14H,9,15H2,1-4H3;1H
InChi Key
RADLXCPDUXFGFF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $94

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    50 mg

    $328

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    100 mg

    $561

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    250 mg

    $1,052

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    Product Description

    Melitracen is a thymoleptic and tricyclic antidepressant.1,2 It inhibits serotonin (5-HT) uptake in rat brain synaptosomes (IC50 = 670 nM).1 Melitracen (20 and 40 mg/kg) increases the lethality of the α2-adrenergic receptor (α2-AR) antagonist yohimbine (Item No. 19869) in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyttel, J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacol. (Berl) 60(1), 13-18 (1978).

    2. Lapin, I.P. Adrenergic nonspecific potentiation of yohimbine toxicity in mice by antidepressants and related drugs and antiyohimbine action of antiadrenergic and serotonergic drugs. Psychopharmacol. (Berl) 70(2), 179-185 (1980).