A nitrofuran antibiotic and an antiparasitic
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Nifuratel

Item No. 40119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone
CAS Number
4936-47-4
Synonyms
  • Methylmercadone
Molecular Formula
C10H11N3O5S
Formula Weight
285.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(OC(CSC)C1)N1N=CC2=CC=C([N+]([O-])=O)O2
InChi Code
InChI=1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3
InChi Key
SRQKTCXJCCHINN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $65

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    Cayman Chemical
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    Product Description

    Nifuratel is a nitrofuran antibiotic and an antiparasitic.1,2 It is active against G. vaginalis and A. vaginae (MIC90s = 0.25 and <0.125 µg/ml, respectively).1 In vivo, nifuratel (50 mg/kg) reduces parasitic load in a mouse model of L. donovani-induced visceral leishmaniasis and a mouse model of L. major-induced cutaneous leishmaniasis.2 Formulations containing nifuratel have been used in the treatment of vulvovaginal infections and urinary tract infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Togni, G., Battini, V., Bulgheroni, A., et al. In vitro activity of nifuratel on vaginal bacteria: Could it be a good candidate for the treatment of bacterial vaginosis? Antimicrob. Agents Chemother. 55(5), 2490-2492 (2011).

    2. Domínguez-Asenjo, B., Gutiérrez-Corbo, C., Álvarez-Bardón , M., et al. Ex vivo phenotypic screening of two small repurposing drug collections identifies nifuratel as a potential new treatment against visceral and cutaneous leishmaniasis. ACS Infect. Dis. 7(8), 2390-2401 (2021).