An inhibitor of KDMs
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PFI-90

Item No. 40120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-pyridinyl)hydrazide, 2-pyridinecarboxylic acid
CAS Number
53995-62-3
Molecular Formula
C11H10N4O
Formula Weight
214.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(C1=CC=CC=N1)NNC2=CC=CC=N2
InChi Code
InChI=1S/C11H10N4O/c16-11(9-5-1-3-7-12-9)15-14-10-6-2-4-8-13-10/h1-8H,(H,13,14)(H,15,16)
InChi Key
GCZPXNWBXDWHKM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $52

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    100 mg

    $98

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    250 mg

    $234

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    Product Description

    PFI-90 is an inhibitor of lysine demethylases (KDMs).1 It inhibits KDM3B, KDM4B, KDM5A, and KDM6B by 46.8 to 87.1% when used at a concentration of 10 µM. PFI-90 induces cell death in SJSA-1 osteosarcoma and TC-32 Ewing's sarcoma cancer cells (IC50s = 2 and 1 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, J., Hawley, R.G., Woldemichael, G.M., et al. Inhibitors of histone demethylases (PFI-63 and PFI-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. (2021).