A prodrug form of 6-azauridine
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Azaribine

Item No. 40131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS Number
2169-64-4
Synonyms
  • 6-Azauridine Triacetate
  • NSC 67239
Molecular Formula
C14H17N3O9
Formula Weight
371.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleChloroform: Soluble
SMILES
CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O
InChi Code
InChI=1S/C14H17N3O9/c1-6(18)23-5-9-11(24-7(2)19)12(25-8(3)20)13(26-9)17-14(22)16-10(21)4-15-17/h4,9,11-13H,5H2,1-3H3,(H,16,21,22)/t9-,11-,12-,13-/m1/s1
InChi Key
QQOBRRFOVWGIMD-OJAKKHQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $37

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    50 mg

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    100 mg

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    250 mg

    $201

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    Cayman Chemical
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    Product Description

    Azaribine is a prodrug form of the nucleoside analog and immunosuppressant 6-azauridine.1,2 It inhibits viral replication in influenza A- or influenza B virus-infected MDCK cells (EC50s = 0.29-0.8 µM).3 Formulations containing azaribine have previously been used in the treatment of psoriasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Creasey, W.A., Fink, M.E., Handschumacher, R.E., et al. Clinical and pharmacological studies with 2',3',5'-triacetyl-6-azauridine. Cancer Res. 23, 444-453 (1963).

    2. Merkel, P.A., Letourneau, E.N., and Polisson, R.P. Investigational agents for rheumatoid arthritis. Rheum. Dis. Clin. North Am. 21(3), 779-796 (1995).

    3. Park, J.-G., Ávila-Pérez, G., Nogales, A., et al. Identification and characterization of novel compounds with broad-spectrum antiviral activity against influenza A and B viruses. J. Virol. 94(7), e02149-02119 (2020).